Spravato treatment for depression that hasn’t responded to medication

Spravato (esketamine) is an FDA-approved nasal spray for adults with treatment-resistant depression (TRD) — meaning depression that hasn’t improved after trying at least two antidepressants. Unlike traditional antidepressants that work on serotonin, Spravato works on NMDA receptors in the brain and can produce results significantly faster — sometimes within hours or days rather than weeks.

You may be a good candidate if:

• You are an adult (18+) diagnosed with major depressive disorder
• You have tried at least two antidepressants at adequate doses without enough relief
• You are not pregnant and do not have certain medical conditions that would make esketamine unsafe

The best way to find out is a consultation with Tamela Harrison, PMHNP-BC. She’ll review your full history and let you know if Spravato is right for you.

Each session takes about 2 hours total. Here’s what to expect:

• Arrive — check in and get settled in a private, comfortable room
• Administer — you self-administer the nasal spray under Tamela’s supervision
• Monitor — you relax in our office for at least 2 hours while we monitor your blood pressure and wellbeing
• Go home — you’ll need someone to drive you home; you cannot drive after a session

Treatment typically starts with twice-weekly sessions for 4 weeks, then once weekly, then every 1–2 weeks for maintenance.

Many major insurance plans — including Medicare — do cover Spravato for patients who meet the clinical criteria. Coverage varies by plan. Our team will verify your benefits before your first session so there are no surprises.

Spravato sessions are available at our Germantown, Maryland location at 13219 Executive Park Terrace. Please call 240-762-4141 to confirm current availability at our Owings Mills location.

Getting started is simple:

• Step 1: Book a consultation — call 240-762-4141 or use the button below
• Step 2: Tamela reviews your history and confirms you’re a candidate
• Step 3: We verify your insurance coverage at no cost to you
• Step 4: Schedule your first in-office Spravato session

Most patients are seen within the same week.

Spravato is FDA-approved and considered safe when administered in a certified clinical setting. Common side effects include dizziness, nausea, dissociation (feeling detached), or temporarily increased blood pressure — all of which typically resolve within 2 hours of the session. This is why all sessions are supervised and you are monitored before going home. Tamela will review your full medical history to make sure Spravato is safe for you before treatment begins.